Leonard: I'll be on a ship in the North Sea.
Penny: On a ship? Aren't they afraid Hawking will just roll overboard?
Leonard: Uh, he's not gonna be there. He's just sending a team to research his theory.
Penny: Oh, sure. Like when you send me to kill spiders in your bathtub.

Penny: At one point, they had me figure out how to get a banana out of a puzzle box.
Leonard: Wait, Sheldon gave me a banana in a box. He was testing me, too.
Penny: Unbelievable.
Leonard: And how could a chimp even solve that? That was impossible.
Penny: Really? You couldn't get it out?

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: Sheldon's nervous about me leaving. Just keep an eye on him while I'm gone.
Penny: Oh, I don't know. Remember what happened when I took care of your goldfish?
Leonard: Well, flush Sheldon down the toilet and get me a new one.

Raj: Okay, I have a request to make.
Amy: And now he can talk. I want to cut open your brain and see what the heck is going on in there.

Bernadette: You know, one of the things that helped me get through Howard being in space for so long was getting married before he left.
Penny: Bernadette, sweetie, shut up.