Penny: Sheldon, she wanted to share a toothbrush holder with you, and now you're at an ice cream parlor trying to pick up women!

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: My mother was at bible study. I walked in the house expecting to find it empty, and I heard a sound coming from my parents' bedroom. When I opened the door, I saw my father having relations with another woman.
Penny: Oh, that's awful!
Sheldon: I know. It's also why I never open a door without knocking three times. I mean, the first one's traditional, but two and three are for people to get their pants on.

Sheldon: Being with Amy has awoken the sexual creature within. When I see a pretty gal walking down the street, I think, "hubba hubba" like any other guy.
Penny: You kiss your mother with that mouth? 'Cause it's fine.

Bernadette: Uh, I left my phone downstairs!
Howard: Damn, so did I.
Bernadette: Wait, I have my iPad.
Howard: What are you going to do, e-mail 911?