Leonard: All right, maybe I overreacted. So we're in two different places emotionally. So what? And maybe I'm a little ahead of you. That's fine. You know. In fact, it makes sense, 'cause let's face it, I've been in this relationship two years longer than you.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: You did this, didn't you?
Wil Wheaton: Come on, Sheldon, do you really think I'd break up a couple just to win a bowling game?
Sheldon: No, I suppose not.
Wil Wheaton: Good. Keep thinking that.
Sheldon: Wheeeeatoooon!

Sheldon: Well, well, well, if it isn't Wil Wheaton. The Green Goblin to my Spider-Man, the Pope Paul V to my Galileo, the Internet Explorer to my Firefox!

Sheldon: I am the ball, my thoughts are its thoughts, its holes are my holes.