Leonard: Come here. Tell you a secret?
Penny: What's that?
Leonard: With all these women chasing me, I kind of do feel like Captain Kirk.
Penny: Can I tell you a secret?
Leonard: Sure.
Penny: Keep talking about Captain Kirk, and we're all gonna stop.
Leonard: (impersonating William Shatner) Message received.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Amy: I have a lab full of coked up monkeys with nothing to lose.

Raj: I did the research. Tony the Tiger, Dig'em the Frog, Cap'n Crunch, Toucan Sam, Count Chocula, Trix the Rabbit, Snap, Crackle and Pop. Not one cereal mascot is a girl. It's a total breakfast sausage fest.
Leonard: Are we done with this?
Raj: Almost. Franken Berry, Boo Berry, Sugar Bear and the Honey Nut Cheerio bee, I believe his name is Buzz.

Sheldon: My father used to say that a woman is like an egg salad sandwich on a warm Texas day.
Alex: What?
Sheldon: Full of eggs and only appealing for a short time.