Leonard: How was Nebraska?
Penny: Oh, better than North Dakota! [silence] I guess that joke's only funny in Nebraska.
Sheldon: From the data at hand you really can't draw that conclusion. All you can say with absolute certainty is that that joke is not funny here.
Penny: Boy, it's good to be back.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Mrs. Wolowitz Howard, it's the phone.
Howard: I know it's the phone, Ma. I can hear the phone.
Mrs. Wolowitz Well who's calling at this ungodly hour?
Howard: I don't know.
Mrs. Wolowitz Well ask them why they're calling at this ungodly hour.
Howard: How can I ask them when I'm talking to you?

Sheldon: Checkmate.
Leonard: Oh, again?
Sheldon: Obviously, you're not suited for three dimensional chess. Perhaps three dimensional Candy Land would be more your speed.
Leonard: Just reset the board!
Sheldon: It must be humbling to suck on so many levels.

Sheldon: Wait, put this in the bathroom.
Leonard: What for?
Sheldon: I need to measure my fluid intake and output to make sure my kidneys aren't shutting down.
Leonard: I mix pancake batter in this!
Sheldon: No, that measuring cup has always been for urine.
Leonard: You had time to make a label for everything in this apartment, including the label maker, but you didn't have ten seconds to make a label that said "urine cup"?
Sheldon: It's right here on the bottom.
Leonard: Huh, I guess I owe the Betty Crocker Company a letter of apology.