Leonard: Well, what are you going to do, Sheldon, give up?
Sheldon: Yes. That's what a rational person does when his entire life's work is invalidated by a post-pubescent Asian wunderkind. He ceases his fruitless efforts, he donates his body to scientific research, and he waits to die.
Penny: You know, I'm confused again. Is he waiting, or do we get to shoot him between the eyes?

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Raj: Can you believe it! He watched me work for 10 minutes and than he tried to build a little piece of software that could replace me.
Leonard: Is that really possible?
Raj: As it turned out, yes.

Sheldon: Engineering. Where the noble semiskilled laborers execute the vision of those who think and dream. Hello, Oompa-Loompas of science.

Leonard: Okay, Sheldon, I understand that youre going through a bit of a career crisis, you're searching for some other area where you can feel valuable and productive but I need to tell you something and I want you to listen carefully.
Sheldon: All right.
Leonard: Go away!