Penny: I guess I could probably try a little harder.
Bernadette: You could start by taking an interest in his work.
Penny: Yeah, that's kind of a problem.
Amy: Why?
Penny: Not really clear on what he does.
Bernadette: He's an experimental physicist.
Penny: Yeah, I'm not really clear on what that means.
Amy: He takes hypotheses and designs protocols to determine their accuracy.
Penny: Yeah, you're really just making it worse.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Stuart: Hey. Hey, look at you guys!
Amy: I'm Raggedy Ann, and he's Raggedy C-3PO.
Sheldon: It was a compromise. I lost.

Howard: A week ago, I was an astronaut.
Bernadette: Yeah, well, today you're a Smurf! Keep moving!

Howard: Okay, here it is. Bernadette said you guys are all sick of me talking about my trip to space. Is that true?
Sheldon: Yes.
Raj: No.
Sheldon: We seem to have different approaches here. I was going for helpful honesty. I have no idea what you're doing.
Raj: It's called being nice.
Sheldon: Okay. If you think being nice will get him to shut up, I'll try it.