Amy: I simply pointed out that they would never consider doing an article ranking male scientists on their sexuality. Let alone showing them in various stages of undress.
Bernadette: Because no one wants to see Neil deGrasse Tyson in a wet t-shirt bent over the hood of a Porsche.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Penny: You locked them in your basement?
Dr. Lorvis: Well, they're not locked in. The door just sticks.
Penny: Okay, so how do they unstick it?
Dr. Lorvis: They'd need the key.

Penny: Okay, you can't just go chasing after every girl who's nice to you.
Dr. Lorvis: Well, that's not what Sheldon says, and he seems to know his way around the ladies.

Leonard: Wow, Donkey Kong. This was my game when I was a kid.
Sheldon: Because it's a story of a pretty blonde girl tirelessly pursued by a small oddly-shaped man?