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Quote from the episode The Jiminy Conjecture

Raj: I don't like bugs, okay? They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Quote from the episode The Lizard-Spock Expansion

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Quote from the episode The Gorilla Experiment

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Quote from the episode The Griffin Equivalency

Sheldon: I'm not insane. My mother had me tested!

Quote from the episode The Comic Book Store Regeneration

Sheldon: May I say something?
Leonard: Not right now, Sheldon.
Sheldon: But I think it may be comforting.
Leonard: Buddy-
Howard: No, it's okay. What?
Sheldon: When I lost my own father, I didn't have any friends to help me through it. You do.

Quote from the episode The Boyfriend Complexity

Leonard: You'll never guess what just happened.
Sheldon: You went out in the hallway, stumbled into an inter-dimensional portal, which brought you 5,000 years into the future, where you took advantage of the advanced technology to build a time machine, and now you're back, to bring us all with you to the year 7010, where we are transported to work at the think-a-torium by telepathically controlled flying dolphins?
Leonard: No. Penny kissed me.
Sheldon: Who would ever guess that?

Quote from the episode The Fortification Implementation

Amy: What are we doing? This is a fort. Let's sit on the floor.
Sheldon: Roughing it? Okay. *sits on floor. Gasps* Everything looks so big from down here. This must be how Leonard feels.

Quote from the episode The Fortification Implementation

Sheldon: I'll get the blankets, you Google how to have child-like fun.

Quote from the episode Pilot

Leonard: Our babies will be smart and beautiful.
Sheldon: Not to mention imaginary.

Quote from the episode The Colonization Application

Sheldon: I'm exceedingly smart. I graduated college at fourteen. While my brother was getting an STD, I was getting a Ph.D. Penicillin can't take this away.

Quote from the episode The Colonization Application

Sheldon: Hi little guy. How'd you like to come home with us? You'll be living with me, because we don't live in the same house.
Amy: But that's not your fault. Like you, we're taking it ridiculously slow. You'll stay with me when he's away for Comic-Con or with work.
Sheldon: Or if they accept daddy's application to live on Mars.

Quote from the episode The Commitment Determination

Penny: Wait, what is wrong with you two? He was talking about television during their date night.
Sheldon: Oh, not just date night. Our 5th anniversary.
Penny: Okay, see, that's even dumber than you wondering if being bitten by a goat would give you the powers of a goat.
Sheldon: If that happens, don't make me wait ten years to watch you eat a tin can.

Quote from the episode The Prestidigitation Approximation

Penny: Oh, big deal. Not knowing is part of the fun.
Sheldon: "Not knowing is part of the fun." Was that the motto of your community college?

Quote from the episode The Maternal Congruence

Sheldon: I made tea.
Leonard: I don't want tea.
Sheldon: I didn't make tea for you. This is my tea.
Leonard: Then why are you telling me?
Sheldon: It's a conversation starter.
Leonard: That's a lousy conversation starter.
Sheldon: Oh, is it? We're conversing. Checkmate.

Quote from the episode The Colonization Application

Sheldon: Being in close quarters, cleanliness is important. My hygiene is impeccable. In fact, animals don't trust me because I smell like nothing. Literally, nothing.

Quote from the episode The Focus Attenuation

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Quote from the episode The Troll Manifestation

Sheldon: Can I respond now?
Leonard: Do it.
Sheldon: You mess with the bull, you get the horns. I'm about to show this guy just how horny I can be.
Leonard: Somebody else do it.

Quote from the episode The Relationship Diremption

Sheldon: (on Stephen Hawking's voice mail) I kiss girls now.

Quote from the episode The Junior Professor Solution

Sheldon: The correct animal for inter-species super soldier is koala. You would wind up with an army so cute, it couldn't be attacked.

Quote from the episode The Colonization Application

Penny: This is why I've been saying we should keep champagne on ice.
Sheldon: Sarcasm?
Amy: Yes.
Sheldon: That was tricky because when it comes to alcohol, she generally means business.

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