Leonard: I'm no expert, but I think the hook has to go through the worm.
Howard: Fine. Sorry, Mr. Worm. Sherm. Sherm the Worm.
Penny: Hey, don't name him. Just jab a hook in his face.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: You know, its a tad old-school, but my father was not one to spare the rod when my brother would sneak into his truck and drink his driving whiskey.
Amy: You want to spank me?

Amy: I don't need your medicine. I'm not really sick. I got better two days ago.
Bernadette: I don't understand.
Amy: It's been so nice having Sheldon take care of me, I just wanted that to last longer.
Bernadette: You should tell him.
Amy: I know.
Sheldon: (From the other room) Amy! Are you strong enough to bathe yourself, or do you need my help?
Amy: I'll tell him tomorrow. Mama needs a bath.

Sheldon: Amy's taking me to a memorial service. It's for one of her colleagues who is of Asian descent, so my planned conversational gambit is to casually remark that no matter how deep they dig his grave, he'll never make his way back to China.
Leonard: That should lighten the mood.
Sheldon: What can I say? I put the fun in the funeral.