Leslie: Just so we're clear, you understand that me hanging back to practise with you is a pretext for letting you know that I'm sexually available.
Leonard: Really?
Leslie: Yeah, I'm good to go.
Leonard: I thought you weren't interested in me.
Leslie: That was before I saw you handling that beautiful piece of wood between your legs.
Leonard: You mean my cello?
Leslie: No, I mean the obvious crude double entendre. I'm seducing you.

Howard: We'll just have to face Sheldon mano y mano y mano a mano.
Leslie: Wait, you're going up against Sheldon Cooper?
Howard: Yes!
Leslie: That arrogant, misogynistic, East Texas doorknob that told me I should abandon my work with high-energy particles for laundry and child bearing?
Leonard: She's in!

Leslie: Listen Leonard, neither of us are neuro-scientists, but we both understand the bio-chemistry of sex, ... I mean: Dopamine in our brain is released across synapses causing pleasure. You stick electrodes in a rat's brain, give him an orgasm button and he'll push that thing 'till he starves to death.
Leonard: Who wouldn't?

Dr.Gablehauser: Need to get that, Dr. Cooper?
Sheldon: God, no.
Leslie: Don't turn it off, you might miss the Nobel Prize Committee saying that you won "Dumbass Scientist of the Year."

Leslie: Hello men. Sheldon.

Dr. Gablehauser: What colorful nickname did you call Dr. Cooper this time?
Leslie: Dr. Dumbass.

Leslie: Oh, Leonard, you magnificent beast.

Leslie: There's no reason to feel uncomfortable just because we've seen each other's faces and naked bodies contorted in the sweet agony of coitus. Rest assured that any aspects of our sexual relationship regarding your preferences, your idiosyncrasies, your performance, are still protected by the inherent confidentiality of the bedroom.

Leslie: Boy, your heart's racing. I must've really gotten you going.
Wolowitz: Well, it's partly you, partly my transient idiopathic arrhythmia.
Leslie: Sexy.

Leslie: Come for the breasts, stay for the brains!