Howard: We'll just have to face Sheldon mano y mano y mano a mano.
Leslie: Wait, you're going up against Sheldon Cooper?
Howard: Yes!
Leslie: That arrogant, misogynistic, East Texas doorknob that told me I should abandon my work with high-energy particles for laundry and child bearing?
Leonard: She's in!

Leonard: Come on, you need a four-person team. We're four people
Sheldon: By that reasoning we should also play bridge, hold up a huppah and enter the Olympic bobsled competition.

Howard: He compared Sheldon to a disposable feminine cleansing product one might use on a Summer's Eve.
Penny: Yeah and the bag it came in.

Sheldon: I will form my own team and will destroy the molecular bonds that hold your matter together, and reduce the resulting particular chaos to tears.
Leonard: Thanks for the heads up.

Howard: Ooh, more details about the new Star Trek film! There is going to be a scene depicting Spock's birth.
Raj: I'd be more interested in a scene depicting Spock's conception.

Sheldon: I need my wrist brace. All this button pushing is aggravating my old Nintendo injury.

Leslie: PMS? It's a couple of days early, but
Leonard: No, it stands for Perpetual Motion Squad.
Leslie: Oh, right, of course, what was I thinking?

Leonard: This is our year, with those guys out, the entire Physics Bowl will kneel before Zod.
Penny: Zod?
Howard: Kryptonian villain, long story.
Raj: Good story. (Covers his mouth upon realizing he spoke to Penny sober)