Bernadette: Come on, let's go home so I can tear off those little pants.
Howard: Great. Just keep in mind astronauts lose a lot of muscle tone in space, so you might have to do most of the heavy lifting.

Howard: Well, that was quick and a little gross. Now I know how she feels.

Penny: Hey, Sheldon, you're always full of fun little facts. Where did the expression get your ass handed to you come from?
Sheldon: Don't know.
Penny: I wonder if it's from like ancient Rome where they'd actually chop somebody's ass off and then go, here. You know, to appease Loseroneous, the God of losers.

Amy: Why don't we do something athletic like go over to the university pool and play water polo?
Leonard: No good, Sheldon doesn't float.
Sheldon: That is true. I have a higher than normal bone density. If I run too deep a bath, I drown.

Sheldon: Wait, I'm a little concerned. Blueberries are rich in antioxidants.
Leonard: So?
Sheldon: So, with all those antioxidants, what if I run out of oxidants?

Raj: Okay, the NASA Web site says Howard's final descent has begun.
Sheldon: He left a boy, he returns a boy-sized hero.

Howard: (singing) Baruch atah, Adonai, Eloheinu. Melech haolam, hamotzi. Lechem min haaretz
Mike: What's that?
Howard: The Jewish prayer for eating bread. We don't have one for falling out of space!

Sheldon: I am not a loser. Pictionary is not a true test of any real intelligence or skill.
Leonard: Mmm. In all fairness, Pictionary has verbal skills, visual skills. It's a pretty well-rounded game.
Sheldon: Lot of big talk from a man who can't draw a chocolate chip cookie.

Amy: Why don't we do something athletic like go over to the university pool and play water polo?
Leonard: No good, Sheldon doesn't float.
Sheldon: That is true. I have a higher than normal body density. If I run too deep a bath, I drown.

Amy: All right, let's keep it simple. How about darts?
Sheldon: No, that's not fair either.
Penny: Why not?
Sheldon: Darts is a bar game. You've been frequenting drinking establishments since you were of legal age.
Leonard: Yeah, that's when it started.

Sheldon: Well, regardless, she has a distinct advantage in all tavern-based competitions. Pool, beer pong, wet T-shirt contests, they're all out.
Penny: Okay. Just for the record, I have never entered a wet T-shirt contest. I've won a few, but that's just because I spill when I'm drunk, so...

Howard: Hey, Ma, twinkle, twinkle, your little star is home. (Fails to open the door) Ma, the chain's on the door.
Mrs. Wolowitz: Howard? I thought I wasn't going to see you till tomorrow.
Howard: Yeah, well, Bernie's not feeling well. So I thought I'd stop by, tell you about the greatest adventure of my life, see if you can make me feel bad about it.
Mrs. Wolowitz: Uh, uh, okay. Hold on, I'm not decent.
Howard: All right. (Speaking to himself) Woman hasn't tied her robe in 20 years. Suddenly she's not decent?

Howard: Dr. Schneider?
Dr. Schneider: Oh, hello, Howard.
Howard: What are you doing here?
Dr. Schneider: Um, house call.
Howard: Youre a dentist.
Dr. Schneider: Yes. Yes, I am. (Shouting to Mrs. Wolowitz) I think he's on to us!

Sheldon: Hurry up, find him, find him.
Leonard: I'm trying. Don't yell at me.
Sheldon: For goodness' sake, he's wearing a hat, glasses, and a red striped shirt.
Leonard: I know what he looks like.
Amy: Oh, there he is, I got him.
Penny: Yes, we win again.
Sheldon: How could you not find him?
Leonard: Because he's hard to find. If he was easy to find, the books would be called There's Waldo!

Raj: Oh, my God, you're back. Oh, look at you. You, you look like you grew.
Howard: Yeah. The lack of gravity did decompress my spine, so I'm like an inch and a half taller. I'm going to the DMV tomorrow to get my license changed before I shrink back.