Sheldon: By the way, how are you with zippers?
Penny: Why?
Sheldon: Well, I really need to go to the bathroom, and this ones gone all cattywampus.

Howard: Check it out. Mrs. Davis from Human Resources is here. She's probably on the lookout for sexual harassment.
Raj: Oh, great. There go my chances of being sexually harassed.

Penny: This is ridiculous. Why am I upset just because hes off having a good time?
Sheldon: Well, perhaps you're obsessively picturing him engaged in drunken coitus with another woman. Is that it? Did I get it right?
Penny: Okay, that- that's great. You can stop trying to make me feel better now.
Sheldon: Actually, I can't. Before Leonard left, he made me promise that I'd take care of you.
Penny: He did?
Sheldon: Yes.
Penny: Oh, that's really sweet.
Sheldon: Plus, if I do a good job, he said he'd bring me back a Sailor's cap.

Penny: Okay, look, here's something people do not know about me. When I first moved out to L.A., I did a topless scene in a low-budget horror movie about a killer gorilla. Ugh, after I did it, I felt so ashamed. Thankfully, that thing never came out.
Sheldon: I've seen that. Yeah. "Serial Apeist". Howard found it online the day we met you.
Penny: Oh, God.
Sheldon: And it was literally the moment you walked out the door.

Raj: If you like dry, factual statement interspersed with awkward silence, it was bananas.

Raj: You think you're so cool because your wife is a person?

Amy: So I can drink this drink without giving up the goodies?

Raj: I think you'd be pleased to hear that this morning in the parking garage I saw this oil stain on the ground that was shaped just like my ex-girlfriend, Lucy, and I didn't get upset at all.
Howard: I'm proud of you.
Raj: Well, you should be, 'cause she was looking good.

Bernadette: (on the phone) Howie, stop. I can't talk like that. Amy's right here.
Amy: (on the phone) Sheldon, stop. For the last time, I will not bring home bed bugs.
Bernadette: The hotel's nice. There's a pool, a gym, the bar looks like fun.
Amy: Because I looked in the bed, and there are no bugs.
Bernadette: Aw, I love you, too. If I don't talk to you before you go to sleep, I'll meet you in dreamland.
Amy: Good night. No, I will not consider sleeping in my garment bag.

Bernadette: I was thinking of going to the lecture on posterior cingulate cortex lesions in the formation of autobiographical memory.
Amy: Oh, brain lesions are fascinating. Unless they're yours, then they're a drag. Bernadette: To the advancement of science.
Amy: And to the sick and dying who make it possible.

Amy: Well, it sounds like you're saying that I could do better than Sheldon.
Bernadette: Boy, these drinks are strong. Oh mama, I'm gonna be huggin' the toilet tonight.
Amy: No, tell me, I want to know what you meant by that.
Bernadette: I just meant that you're not married and your boyfriend's kind of, Sheldon.
Amy: And your husband is extremely Howard.

Penny: I can't believe it. All this time I've been doing nothing but sit around and miss that guy. And you know what the worst part is?
Sheldon: That you're having to process your emotional pain without vodka?
Penny: No. Yeah.

Sheldon: Allow me to comfort you. At least you've got your health.
Penny: Really? That, that's it? That's comforting?
Sheldon: Um, uh, in a hundred years, you'll both be dead and it won't matter?
Penny: No. Come on, you're supposed to say, "Of course he misses you, the only reason he's partying is to cover up his pain."
Sheldon: Oh, no, I don't think that's true at all.

Raj: I'd like to apologize for being insensitive. And for possibly making penguins seem like jerks, because 99% of them are stand-up guys.

Sheldon: Here is a hot beverage to comfort you. It's in a to-go cup. Make of that what you will.