Sheldon: All right, well, we should head out now if we're gonna get to the airport six hours before boarding.

Leonard: Are you kidding me? You just found out that a woman who has loved and cared for you for 12 years is pregnant, and all you can say is you're relieved that she's not gonna get you sick?
Sheldon: There's no need for a recap. I was there.

Amy: Why didn't you tell me?
Penny: I didn't tell anybody.
Amy: I'm not anybody. I'm your best friend.
Bernadette: What's going on?
Amy: She's pregnant.
Bernadette: That's fantastic! Why didn't you tell me?
Amy: She didn't tell me, either.
Bernadette: But I'm her best friend.
Amy: [chuckles] We'll get into that later.

Bernadette: Now, Michael, Mommy and Daddy are going away for a couple days, so if you're gonna say your first words, you got to do it now or wait till we get back.

Amy: Thank you, your majesties. Thank you to the Nobel Committee. We are deeply honored. I would just like to take this moment to say to all the young girls out there who dream about science as a profession: go for it. It is the greatest job in the world. And if anybody tells you you can't, don't listen. And now, speaking of not listening, my husband, Dr. Sheldon Cooper.

Amy: I think you need to do some editing, like maybe cut out all that stuff about your childhood.
Sheldon: Are you kidding? Growing up in the backwoods of East Texas is what makes me warm and relatable.
Amy: Well, what about all these pages calling out everyone who said you wouldn't succeed?
Sheldon: I told them all they would rue the day. How is it gonna make me look if the day finally comes, and they're not filled with rue?

Sarah Michelle Gellar: Just to be clear, this isn't a date.
Raj: Yeah, I know.
Sarah Michelle Gellar: Then why are you holding my hand?

Leonard: Oh, don't slam the-
Sheldon: Don't slam the [gasps] That was exhilarating.

Penny: Pickled herring. Who knew how good it was!
Leonard: Really? Sounds gross.
Penny: Looks gross. Smells gross. It's delicious! [knock on door] Ooh, that might be my salted cod!

Howard: Somebody just peed in the big girl potty.
Bernadette: Oh, I'm so proud! It was her, right?
Howard: Yes.

Leonard: What kind of DNA is this, anyway?
Sheldon: I was trying to design the genetic code of an advanced race of human being. One of my rare failures, actually.
Leonard: What went wrong?
Sheldon: The balls kept sticking to my pants.

Leonard: What?
Amy: Sheldon has something he'd like to say.
Sheldon: I'm sorry I didn't react appropriately. You and Penny are bringing new life into the world. Congratulations. I can't wait to meet it.
Leonard: "It"?
Sheldon: That's a gender-neutral pronoun. If you're offended, take it up with the English language.

Sheldon: Hello? What did we just learn about the end of business meetings? [everyone groans as they shake each other's hands]

Amy: Sheldon, this isn't about ruing. This is about humbly accepting a great honor.
Sheldon: Amy, we won the Nobel Prize in Physics. Humility is for people who win the goofy Nobels like Literature, Economics and Peace.
Amy: Please tell me that's not in your speech.
Sheldon: Oh. I can cut it, but it's the only joke I have.

Leonard: You pick up your dresses?
Amy: Yep. The tailor had to take mine in and let Penny's out. Best day of my life.
Sheldon: What about the day you met me?
Amy: I stand by my statement.