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Quote from Sheldon in the episode The Change Constant

Sheldon: Six times ten to the eighth atoms, Of a radium in a lead jar, Six times ten to the eighth atoms of radium, If the half-life of radium should happen to pass, Three times ten to the eighth atoms, Of a radium in a lead jar.
Penny: Really hope you're almost to zero.
Sheldon: No, see, that's the beauty of half-lives: it's impossible to determine when you'll arrive at zero. It's like "Wheels on the Bus" if the bus had an unknowable number of parts.

Quote from Leonard in the episode The Change Constant

Penny: Yeah, we're gonna need more coffee.
Amy: Yep. I'm with you.
Penny: Leonard, coffee?
Leonard: Black and strong, like Luke Cage.
Penny: I'm too tired to even be disturbed by that.

Quote from Amy in the episode The Change Constant

Penny: Sheldon?
Sheldon: Mm, absolutely not, no. The Nobel committee will be making the calls to inform the winners at any minute, so the only drug I need is the endorphins pumping through my brain in anticipation of our victory.
Amy: Well, technically, anticipation wouldn't be mediated by endorphins as much as dopamine, but, you know, you've been up all night, so I'll give you that one. [Amy looks and sees Sheldon is asleep] Really? The second he stops talking?

Quote from Leonard in the episode The Change Constant

Penny: Well should we wake him up?
Leonard: Well, he did say if he fell asleep, we were allowed to slap him awake.
Penny: Oh, boy.
Leonard: Wait a minute. Why do you get to do it?
Penny: 'Cause I called it.
Leonard: Well, you can't just call it. You have to earn it.
Penny: Oh, and you've earned it?
Leonard: No one has earned it more than me. [Amy clears her throat] You have your whole life to smack him around. This is my time.

Quote from Leonard in the episode The Change Constant

Penny: Fine. Don't miss.
Leonard: It's not a volleyball. I can handle it.

Quote from Leonard in the episode The Change Constant

Penny: Oh, wait. Hang on. When you're old, you are gonna want a record of this.
Leonard: Oh, oh, yeah. Do it in slo-mo. I want to see his cheeks ripple.

Quote from Barry Kripke in the episode The Change Constant

Sheldon: It's happening! [phone chimes] Unknown caller. It's got to be them.
Amy: Okay, put it on speaker.
Sheldon: Hello?
Amy: Hi.
Barry Kripke: Hello. This is Sweden calling. Is this Dr. Cooper and Dr. Fowler?
Sheldon: Yes.
Amy: Yeah.
Barry Kripke: Congratulations. It is my pleasure to inform you that you've won the Nobel Prize in being suckers!

Quote from Bernadette in the episode The Change Constant

Sheldon: What do you want, Howard?
Howard: We were just calling to see if you'd heard yet.
Sheldon: We haven't.
Amy: But thank you for getting up so early to call. That was very thoughtful.
Bernadette: Oh, please. We have two little kids. We've been up for an hour.

Quote from Howard in the episode The Change Constant

Howard: Did anyone get to slap Sheldon?
Leonard: No.

Quote from Sheldon in the episode The Change Constant

Penny: All right, now what?
Sheldon: Oh, why don't we play a game to pass the time? Here. Uh, I am thinking of a number. Hint: it's a cube of a cube of a prime.
Leonard: There's an infinite number of possibilities.
Sheldon: What, you got somewhere to be?

Quote from Sheldon in the episode The Change Constant

Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Penny: Congratulations!
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!

Quote from Sheldon in the episode The Change Constant

Sheldon: And how does it feel to be married to a Nobel Prize winner?
Amy: You tell me.
Sheldon: Oh. Amy-centric. What a fun way to look at it.
Amy: I think so.
Sheldon: You would. That makes sense.

Quote from Sheldon in the episode The Change Constant

Sheldon: It's a congratulations text from my meemaw. [phone vibrates] Ooh. Oh, and there's one from my mom. [phone vibrates] And my sister. [phone vibrates] Oh, and my brother. [phone vibrates] And my brother's ex-wife. [phone vibrates] My brother's other ex-wife. Boy, they don't tell you when you win a Nobel it chews up your phone battery.

Quote from Amy in the episode The Change Constant

Amy: Oh, that's me. It's CVS. My prescription's ready. [phone vibrates] Oh, and also my dad. He says congratulations and he loves me.
Sheldon: Nothing about me? [phone vibrates] Oh. Oh, it's your dad. I'm good.

Quote from Sheldon in the episode The Change Constant

Sheldon: You know, when you think about it, now that we're Nobel Prize winners, our names will be linked together forever.
Amy: We're married. Our names are already linked together forever.
Sheldon: Oh, please. That's just a piece of paper. This is a piece of paper and a medal.

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