Sheldon: Are we done talking about Howard's failed conjugal relations? I have an actual Nobel Prize crisis to deal with.
Raj: Has anything changed since the last time you talked about it?
Sheldon: No.
Howard: Is there anything you can do about it?
Sheldon: No.
Raj: Then shut up or go wait in the car!

Raj: Oh man, first monster I see I'm gonna sneak up behind him, whip out my wand and shoot my magic all over his ass!
Stuart: Do you hear yourself when you say these things?

Raj: Amy, good luck getting these guys excited about a dinner with a theme. I gave up when no one cared about my Tom Hanks-Giving.

Penny: What do you mean new roommate? What happened to Leonard?
Sheldon: The same thing that happened to Homo Erectus. He was replaced by a superior species.
Raj: I'm the new homo in town.

Stuart: Whoa, whoa. You're not gonna cut open a meteor, are you? Have you not learned anything from comic books? Space viruses? Pod people? I sell nothing but warnings.

Howard: And then Andy said if we want privacy, we should plant some trees. The only way I know how to do that is to give a dollar and tree shows up in Israel.

Denise: If you want cold medicine, Stuart has the entire run of DayQuils, including the rare "DayQuilt" misprint from 1996.
Stuart: What can I say? I'm a collector.