Penny: Never? Isn't that usually when you go to the gym?

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Sheldon: I'm looking over my text correspondence with Beverly and I don't see anything that would have given her offense. Nothing's ambiguous, I spell everything out. Including "laugh out loud" and "what's the fracas?"

Amy: Are you really not gonna pick up your mother?
Leonard: No. It's fine, she likes to take a cab or a shuttle. That way she can meet people.
Amy: Well, that's kind of nice.
Leonard: Yeah, she always says that a stranger is just a person whose emotional weak point you haven't found yet.
Sheldon: Your mom is the best.

Leonard: How was your flight?
Beverly Hofstadter: There were some parents with a baby. A lot of crying.
Leonard: Well, babies do that.
Beverly Hofstadter: No, it was the parents. It seems they couldn't handle some constructive criticism.