Leonard: Okay, you need to focus on the positive. You won a Nobel Prize. I slapped Sheldon. A lot of dreams came true today.

Sheldon: I remember the song! It's called "Darlin'" by the Beach Boys! Oh, thank goodness! I'm not crazy! I don't have to take a pigeon as my bride!
Leonard: There goes our shot at him living on the roof.

Howard: Don't feel bad. Some day someone will be throwing out your work, too.
Leonard: That someone was Sheldon and the day was yesterday.

Professor Proton: Can I ask you a question?
Leonard: Yeah, sure.
Professor Proton: Why do you put up with Sheldon?
Leonard: Oh, you know because we're friends.
Professor Proton: Why?
Leonard: Wow, you ask really hard questions. Look, I know he can be aggravating, but what you have to remember is he's not doing it on purpose, it's just how he is. But he's also loyal and trustworthy and we have fun together.
Professor Proton: You know you're describing a dog?
Leonard: He did bite me once. But in his defense, I came up behind him while he was eating.
Professor Proton: They hate that.
Leonard: Sheldon is the smartest person I have met. He's a little broken and he needs me. And I guess I need him too.
Professor Proton: Why is that?
Leonard: Boy, you will not let this go, will you?

Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Penny: Congratulations!
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!

Penny: So, I guess the only thing that actually stays the same is that things are always changing.
Sheldon: Interesting. So you're saying the inevitability of change might be a universal constant.
Penny: Well, there's a little more to it than that, but, yeah, sure.

Penny: Well should we wake him up?
Leonard: Well, he did say if he fell asleep, we were allowed to slap him awake.
Penny: Oh, boy.
Leonard: Wait a minute. Why do you get to do it?
Penny: 'Cause I called it.
Leonard: Well, you can't just call it. You have to earn it.
Penny: Oh, and you've earned it?
Leonard: No one has earned it more than me. [Amy clears her throat] You have your whole life to smack him around. This is my time.