Raj: (Reading Bulletin) We are testing a new medication for social anxiety, panic attacks, agoraphobia and obsessive-compulsive disorder. Why would they be looking for test subjects here?
Leonard: I don't know, Raj, maybe the comic store doesn't have a bulletin board.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Rajesh: Missy. Do you enjoy pajamas?
Missy: I guess.
Rajesh: Yes, well, we Indians invented them. You're welcome.
Howard: Yeah, well my people invented circumcision. You're welcome.

Howard: Well, she's free to examine my briefs.
Leonard: Howard!
Howard: I know! I'm disgusting. I should be punished. By her. Oh, look I did it again.

Sheldon: Eat this slice of cheese without farting and you can sleep with my sister.