Leonard: When I made that agreement, I didn't think I'd ever have a hot girlfriend, and I was positive you never would.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Sheldon: I remember the song! It's called "Darlin'" by the Beach Boys! Oh, thank goodness! I'm not crazy! I don't have to take a pigeon as my bride!
Leonard: There goes our shot at him living on the roof.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Bernadette: Does your mother call you every day at work to see if you had a healthy lunch?
Howard: My mother calls me every day at work to see if I had a healthy bowel movement.

Wil Wheaton: Game over, Moonpie.

Wolowitz: Puppies, how do you stand on puppies?
Bernadette: A puppy once bit my face!
Wolowitz: Of course it did.