Raj: I don't believe it!
Howard: Neither do I. Doogie Howser's been off the air for like 20 years.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Leonard: I don't believe it. What's gotten into him?
Penny: Oh, maybe a couple of virgin Cuba Libres that turned out to be kinda slutty.
Leonard: You didn't.
Penny: Hey, you do your experiments, I do mine.

Raj: How can I be a gynaecologist? I can barely look a woman in the eye!

Sheldon: How often does one see a beloved fictional character come to life?
Wolowitz: Every year at ComiCon. Every day at Disneyland. You can hire Snow White to come to your house. Of course they prefer if you have a kid.