Zack: I don't get it.
Leonard: A dolphin might.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Raj: I've said this before and I'll say it again: Aquaman sucks!

Zack: Whoa, you dated Penny?
Leonard: She didn't tell you?
Zack: She told me she dated a guy named Leonard. Who would have thought it was you?
Leonard: Who else would it be?
Zack: I don't know. Somebody bigger and- Yeah, sure. Why not you?

Zack: You know, I saw this great thing on the Discovery Channel. Turns out if you kill a starfish it'll just come back to life.
Sheldon: Was the starfish wearing boxer shorts? Because you might have been watching Nickelodeon.