Bernadette: Whoa, Drinky Smurf.

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Stuart: Hey. Hey, look at you guys!
Amy: I'm Raggedy Ann, and he's Raggedy C-3PO.
Sheldon: It was a compromise. I lost.

Howard: A week ago, I was an astronaut.
Bernadette: Yeah, well, today you're a Smurf! Keep moving!

Howard: Okay, here it is. Bernadette said you guys are all sick of me talking about my trip to space. Is that true?
Sheldon: Yes.
Raj: No.
Sheldon: We seem to have different approaches here. I was going for helpful honesty. I have no idea what you're doing.
Raj: It's called being nice.
Sheldon: Okay. If you think being nice will get him to shut up, I'll try it.