Leonard: (To Penny) Way to hit 'em with both barrels.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: Well, that's a fine how-do-you-do. (To Amy) Don't just stand there. Take your breasts out.

Amy: Seriously, is that tape? Like, how are they staying up like that?

Amy: You're all wasting your time. Sheldon is the most qualified for the job. And no amount of gravity-defying bosom is going to change that.