Bernadette: Sorry doesn't clean my underpants, buddy.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Howard: She hid my XBOX like I'm a child. And my mom got me that for my birthday so if you don't give it back, I'm telling.

Bernadette: If you like pushing buttons so much, try pushing them on the washing machine.

Howard: A micro-valentine for a microbiologist.
Leonard: From her micro-husband.