Sheldon: I suppose there's no choice but to face the crying, angry accusations, and the high pitch wails of despair.
Penny: Yeah and who knows how Amy will react.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Howard: If you don't leave now, she'll use food and guilt to keep you there the rest of your life.

Howard: Honestly, if I could bend that far what would I need with you.
Bernadette: If you could bend that far, you'd be doing both of us a favor.

Mrs. Wolowitz Oh please. You're a tall glass of brown water. Have dessert.