Sheldon: Well, Leonard, I think it's high time we address the tweepadoc in the room.
Leonard: The what?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: Careful, Amy. The friend of the enemy's girlfriend is my enemy.
Amy: Really?
Sheldon: You're either with me or against me.
Amy: You wanna take the bus to work?
Sheldon: Maybe there's a third option.

Amy: What does tweepodoc mean?
Sheldon: Elephant?
Amy: Lucky guess.

Leonard: Leonard: I didn't make it back. The ship sank. I'm in Hell.