Leonard: Well, uh, okay, um, I dont want to get back together with Penny. We tried it, it was crazy, it didn't work, but I can't deal with the fact that she slept with my friend Raj. And then I find out that Raj's sister Priya, who I've been going out with for eight months, is moving back to India. So I'm just completely confused and alone.
Beverly Hofstadter: I understand.
Leonard: Got any advice?
Beverly Hofstadter: Yes. Buck up.
Leonard: Excuse me. You're a world-renowned expert in parenting and child development, and all you've got is buck up?
Beverly Hofstadter: Sorry. Buck up, sissy pants.

Beverly Hofstadter: So, Howard, have you and Rajesh finally summoned the courage to express your latent homosexual feelings towards one another?

Beverly Hofstadter: Hello, Leonard.
Leonard: Mom?
Beverly Hofstadter: I understand you have been whining about my parenting in order to emotionally manipulate your girlfriend.

Beverly: Let's discuss why you continue to involve me in your sex life.
Leonard: Oh, please no mommy. No mommy.
Beverly: When you were six years old, you walked in on me and your father naked. I was swatting his bottom with your brand new ping-pong paddle.
Leonard: I didn't dream that!?
Beverly: How did that make you feel?

Sheldon: For the record, I do have genitals. They're functional and aesthetically pleasing.

Amy: A guest in my trundle bed and a boy at my door. I wish I could tell thirteen-year-old me it does get better.

Sheldon: If it's good enough for Kirk, Crunch, and Kangaroo it's good enough for me.