Beverly Hofstadter: It might explain why the two of you have created an ersatz homosexual marriage to satisfy your need for intimacy.
Howard: Say what?

Leonard: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Beverly Hofstadter: If you want to have intercourse with that girl, find out what kind of cologne her father wore.

Penny: I'm curious. What was Leonard like when he was little?
Beverly Hofstadter: I think you mean young. He's always been little.

Penny: You can't let her get into your head.
Leonard: It's too late for me, my head is her summer house.

Leonard: That was fast.
Beverly Hofstadter: Oh, the middle stall was occupied. I'll have to try again later.
Sheldon: That's totally understandable. In bladder voiding, as in real estate, it's location, location, location.

Beverly Hofstadter: Aside from a pro forma consummation of our marriage, his father and I only had intercourse for the purposes of reproduction.
Sheldon: That seems a fairly efficient arrangement.
Beverly Hofstadter: Yes, we think so. We've both done papers on it. Mine from the neuroscientific point of view and his from an anthropological. Mine, of course, was the only one worth reading.
Sheldon: Of course. I would very much like to read about your sex life.
Beverly Hofstadter: Well, it's all online, or you can order it from the Princeton University Press.

Beverly Hofstadter: Well, Leonard's younger brother, Michael, is a tenured law professor at Harvard, and his sister just successfully grew a human pancreas in an adolescent gibbon.
Howard: So, she's close to curing diabetes?
Beverly Hofstadter: Why else would you grow a pancreas in a teenaged gibbon?
Howard: Wow, you must be very proud.
Beverly Hofstadter: Why? They're not my accomplishments. I have to urinate.

Sheldon: Yeah, I'm definitely going with colonoscopy.
Leonard: Okay, bye. (Off the phone) My mother's coming for a visit.
Howard: How about that, you were right.

Beverly Hofstadter: You know, both selective mutism and an inability to separate from one's mother can stem from a pathological fear of women. It might explain why the two of you have created an ersatz homosexual marriage to satisfy your need for intimacy.

Beverly Hofstadter: Your scan data will be very helpful to my research. You have a remarkable brain.
Sheldon: I know. Although, I've always hated how my right frontal lobe looks in pictures.
Beverly Hofstadter: Common complaint among men. Nothing's ever big enough. Except when they get a tumor, Then you never hear the end of it.

Penny: It's out of order.
Beverly Hofstadter: Yes, I can read the sign. I was just pondering the implications.
Penny: I think it implies that the elevator doesn't work.
Beverly Hofstadter: Again, I can read the sign. But the sign and the tape are covered with a layer of dust which indicates the elevator has been non-functional for a significant period of time, which suggests either a remarkable passivity among the - I assume - 24-36 residents of this building - based on the number of mail boxes and typical urban densities - or a shared delusion of functionality.

Penny: You must be Leonard's mother.
Beverly Hofstadter: Well, I don't know whether I must be, but yes.

Leonard: So, Mother, what's new?
Beverly Hofstadter: You'll have to be more specific.
Leonard: All right. Uh, what's new with you?
Beverly Hofstadter: Oh, well, I've been having some fascinating menopausal symptoms recently.
Leonard: Maybe something less personal.
Beverly Hofstadter: Oh. Your Uncle Floyd died.
Leonard: Oh, my God. What happened?
Beverly Hofstadter: His heart stopped beating. I have to urinate.

Leonard: You shush. I'm happy. I want to talk about it.