Penny: I'm curious. What was Leonard like when he was little?
Beverly Hofstadter: I think you mean young. He's always been little.

Leonard: Well, uh, okay, um, I dont want to get back together with Penny. We tried it, it was crazy, it didn't work, but I can't deal with the fact that she slept with my friend Raj. And then I find out that Raj's sister Priya, who I've been going out with for eight months, is moving back to India. So I'm just completely confused and alone.
Beverly Hofstadter: I understand.
Leonard: Got any advice?
Beverly Hofstadter: Yes. Buck up.
Leonard: Excuse me. You're a world-renowned expert in parenting and child development, and all you've got is buck up?
Beverly Hofstadter: Sorry. Buck up, sissy pants.

Beverly Hofstadter: So, Howard, have you and Rajesh finally summoned the courage to express your latent homosexual feelings towards one another?

Beverly Hofstadter: She doesn't have much in the way of career prospects, and don't make her responsible for her own orgasms as well.

Beverly Hofstadter: It might explain why the two of you have created an ersatz homosexual marriage to satisfy your need for intimacy.
Howard: Say what?

Leonard: She's only been here a day and a half, and I'm seriously considering alcoholism as a new career path.
Penny: Hey, I talked to her for five minutes yesterday, and I've been half bombed ever since.

Beverly Hofstadter: If you want to have intercourse with that girl, find out what kind of cologne her father wore.