Mrs. Wolowitz What's going on? Are you boys roughhousing?
Howard: We're just talking, ma.
Mrs. Wolowitz If you don't settle down right now, I'm not going to let you have any more sleepovers.

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Mrs. Wolowitz Howard, it's the phone.
Howard: I know it's the phone, Ma. I can hear the phone.
Mrs. Wolowitz Well who's calling at this ungodly hour?
Howard: I don't know.
Mrs. Wolowitz Well ask them why they're calling at this ungodly hour.
Howard: How can I ask them when I'm talking to you?

Mrs. Wolowitz It's this dress. When I put my front in, my back pops out. When I put my back in, my front pops out. It's like trying to keep two dogs in a bathtub.
Sheldon: What do you want me to do?
Mrs. Wolowitz We're gonna have to work as a team. Get in here, grab a handful and start stuffing.

Sheldon: I wouldn't tell you the secret. Sssh!
Leonard: What secret? Tell me the secret.
Sheldon: Mom smokes in the car. Jesus is okay with it, but we can't tell dad.
Leonard: Not that secret, the other secret.
Sheldon: I'm Batman! Ssssh!

Penny: Sheldon, could I ask you a question?
Sheldon: I would prefer that you not, but I wouldn't go so far as to forbid it.

Leonard: How could you just sit there and let them spy on me?
Sheldon: They were very smart. They used my complete lack of interest in what you are doing.