Howard: I guess the sad truth is not everyone will accomplish something great. Some of us may just have to find meaning in the little moments that make up life.
Leonard: That's a nice way of looking at it.
Howard: Yeah, for you, not for me. I went to space, so I'm covered.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Howard: I invented a game. Want to play?
Leonard: Sure.
Howard: It's called Emily or Cinnamon. I give you actual quotes I've heard Raj say, and you guess if he was talking to his girlfriend or his dog.

Bernadette: Does your mother call you every day at work to see if you had a healthy lunch?
Howard: My mother calls me every day at work to see if I had a healthy bowel movement.

Sheldon: I'd like to take a moment to personally thank Dr. Amy Farrah Fowler, who you may or may not know is the first woman to co-host a flag or banner related Internet infotainment show.
Amy: Take that glass ceiling!

Leonard: You know what, this bottle was meant to celebrate an achievement. Let's make a pact. When one of us gets their first big breakthrough, we'll celebrate by opening this bottle and toasting Professor Abbott.
Howard: I love that.
Raj: Me too.
Leonard: Then, of course, rubbing our success in Sheldon's face.
Howard: Well that's the best part.

Amy: Sheldon, that was beautiful.
Sheldon: If you didn't press record-
Amy: I pressed it!