Leonard: Ethyl alcohol inhibits electrical conduction in the nerve cells and stimulates re-uptake receptors of inhibitory neurotransmitters like gamma-amino butyric acid.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Wolowitz: I think that you and Penny had a poor night.
Leonard: It wasn't poor. It was ... just fine.
Raj: Dude, the fourth Harry Potter movie was just fine.

Raj: Ooo, big talk from a man who was once treed by a chicken.