Leonard: Do you think Penny's mad at me?
Bernadette: Because you're in the right lane behind a bus and you won't go around it? I'm sure she finds it charming.
Leonard: No, because I didn't want her on my team.
Bernadette: I'm starting to think she dodged a bullet. The slowest bullet in the world.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Penny: [to Raj] Run to India.

Amy: As my mom used to say, "When you're doing a puzzle, it's like you've got a thousand friends." She was full of fun lies like that.

Sheldon: My brain is better than everybody's!