Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Penny: Wow, it looks really pretty in here.
Stuart: Yeah, turns out half a dozen Menorahs really sets a mood.

Howard: Oh, man. This is the boutineer from my high school prom. A piece of cake from my Bar Mitzvah.
Bernadette: Did she throw anything away?
Howard: No. If I find my foreskin, I'm gonna kill myself.

Sheldon: Is it my fault I have a much bigger reputation than he does?
Amy: It's not your fault.
Sheldon: Is it my fault that my name came first on the paper alphabetically?
Amy: Not your fault.
Sheldon: Is it my fault that when the reporter cited me as the lead scientist, I didn't correct him?
Amy: Hey look at that pretty bird.