Sheldon: Wil Wheaton, go.
Wil Wheaton: Sheldon, I know that we've had our ups and downs, but I can honestly say that my life is so much more interesting because you are in it. We may have met because you are a fan of Star Trek. But I have become a fan of Sheldon Cooper. Live long and prosper, buddy. And happy birthday.
Sheldon: That's how you do it, Wolowitz. Now you see why he's famous and you're not.

Wil Wheaton: Game over, Moonpie.

Wil Wheaton: Did that guy just say "Revenge is a dish best served cold" to me in Klingon?

Wil Wheaton: Hey look, they named their team after me!

Penny: So what's going on?
Sheldon: I don't know. I looked around the room, and I saw all the faces and the presents, and it it was just too much.
Penny: I get that. Hey, you want to just bring a few people in here? You know, Wil Wheaton in the bathtub, Batman on the toilet. It'll be like the weirdest Comic-Con ever.

Leslie Winkle: Uh, in the past, I would've said something obnoxious, like, "Happy birthday, dumbass". But I'm not gonna do it. You and I have both grown a lot, and it's just so nice to see you all again. So happy birthday, Sheldon.
Sheldon: Oh. Oh, now, you know I hate change. Say it.
Leslie Winkle: Happy birthday, dumbass!

Amy: We've got someone who couldn't be here but really wanted to wish you a happy birthday.
Stephen Hawking: Hello, Sheldon.
Sheldon: (gasps) Professor Hawking.
Stephen Hawking: Happy birthday to you.
Sheldon: Thank you so much. I can't believe you're-
Stephen Hawking: Happy birthday to you.
Sheldon: Oh, you're singing. Well, I'm sorry.
Stephen Hawking: Happy birthday, dear Sheldon.
Leonard: Uh, Professor Hawking, if you just give us one second, we'll light the candles, and we can all sing together.
Stephen Hawking: I was crushing it, but all right.