Penny: Oh, my God, Howard. That's the most beautiful thing I've ever heard. And it came out of you.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Barry Kripke: Yes, yes, yes. He's a jolly good fellow. What time do the strippers arrive?

Stuart: Okay, I'll go. Howard, when I think about you and Bernadette starting this wonderful life together, I can't help but get a little choked up. I mean, look at you. You have everything. Look at me. I'm 37. I sleep in the back of a comic book store, and I have the bone density of an 80-year-old man. To Howard.

Raj: When I moved to America I was pretty lonely, but when I met Howard my life changed because we could be lonely together.