Leonard: Wow! An appearance by George Lucas's ... dermatologist. Oh, I want that autograph.
Penny: Oh, yeah.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: Stuart, wait. I do know what it feels like to be left out.
Bert: I know how it feels, too.
Sheldon: All right, this is about me and him; you're not part of it.

Amy: There's nothing to be afraid of, Sheldon.
Sheldon: The average cork speed is 25 miles per hour. If that is too fast around a school, it is certainly too fast around a kitchen.
Amy: Been 15 minutes. Just sayin'.
Sheldon: Okay, I can do this. Just give me a moment. (Cork pops and Sheldon shrieks) Oh! Mimosas coming up.

Penny: Hey, have you ever heard of the Van Nuys Comic-Con?
Leonard: Yeah, it's a dinky little convention where they sell collectibles and get sad D-list celebrities to appear. Why?
Penny: I got asked to sign autographs there.
Leonard: That's awesome! Is this for Serial Ape-ist?
Penny: Well, it could be for the monkey movie. It could be my hemorrhoid commercial. The list does not go on.