Leonard: Stupid idea.
Penny: No, what's stupid is a physicist who doesn't understand when you swing an axe, you don't let go.
Leonard: For the tenth time, my mittens were slippery!
Penny: Ugh. It's 70 degrees, you didn't need mittens.
Leonard: You know how easily I blister.
Penny: Yes, yes, you bruise, you peel. It's like I'm married to an old piece of fruit.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Amy: Well, uh, Howard and Bernadette had their baby.
Mary Cooper: (gasps) Oh, that's wonderful! Now, have they decided to raise it Jewish or regular?
Sheldon: Welcome to Texas.

Bernadette: Everyone's a better mom than me.
Raj: Oh, don't take it so personally, maybe your baby's just a jerk.

Mary Cooper: Sheldon, if you're trying to prove me wrong, the tighty-whities on your head ain't changing my mind.