Howard: You actually think Penny will have fun at Comic-Con?
Leonard: No. Which will make me miserable, which is usually Sheldon's job.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Penny: So, do you want to come?
Amy: No, thanks. I already live in a place all the nerds come to.

Sheldon: He also has a remarkable amount of credit card debt.
Howard: I thought your dad paid your cards.
Raj: I have a card for emergencies that I pay for myself.
Sheldon: What emergency happened at the L.A. Zoo?
Raj: That's a penguin I sponsor. They're losing their homes to global warming, and my car gets, like, seven miles a gallon, so I felt bad.

Leonard: Now we're going as Hulk and She-Hulk. I don't want to take my shirt off at Comic-Con.
Sheldon: If I may speak for Comic-Con, we don't want that either.