Leonard: Hey, Olsen twins!
Penny: What?
Leonard: Well, I mean, I'm sitting right here. You're talking about my feelings and somehow leaving me out of the conversation.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Amy: Wait, are you saying if we combine my experiment with your calculations, we can determine the precise moment in time when the wave function collapses?
Sheldon: It could be the most inspired combination since I mixed red Icee into my blue Icee. It was like drinking 2/7ths of the rainbow.
Amy: Sheldon, this is really interesting.
Sheldon: Yeah and this one won't stain my teeth purple.

Amy: Why don't you ask me what I'm working on?
Sheldon: Oh, very well. What have you been working on? And feel free to honk during the boring parts.

Leonard: Oh, it's just nice to be with people who are happy to have me around. Isn't that right, Halley?
*Halley starts crying*
Howard: Well, at least someone had the courage to say it.