Bernadette: You know, I met a really cute girl at work. She's married to a guy in one of our drug trials.
Penny: Well, hello? She's married.
Bernadette: Yeah, but her husband is in serious congestive heart failure, and a little birdie told me he's in the placebo group.
Penny: Okay, so future grief-stricken widow is the one to beat.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Penny: (Whispers) Here she comes.
Howard: Smart. Whisper so the deaf chick doesn't hear you!

Sheldon: The entrance to the dungeon is a moss covered door. You manage to open it only to find yourself face-to-face with a hideous, foul-smelling, moss-covered ogre. What do you do?
Howard: I say, "Hey Ma, what's for dinner?"

Raj: I don't know if I wanna play any more.
Sheldon: Because you don't have a girlfriend? Well, good lord, if that becomes a reason to not play dungeons and dragons, this game is in serious trouble.