Raj: I don't know if I wanna play any more.
Sheldon: Because you don't have a girlfriend? Well, good lord, if that becomes a reason to not play dungeons and dragons, this game is in serious trouble.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Penny: (Whispers) Here she comes.
Howard: Smart. Whisper so the deaf chick doesn't hear you!

Sheldon: The entrance to the dungeon is a moss covered door. You manage to open it only to find yourself face-to-face with a hideous, foul-smelling, moss-covered ogre. What do you do?
Howard: I say, "Hey Ma, what's for dinner?"

Penny: This girl is trouble. What kind of relationship is it where you buy her gifts and she gives you sex?
Raj: The best one I've ever had!