Leonard: So aren't you going to go talk to her?
Howard: I will, I'm just working on my opening line.
Leonard: She's probably heard every possible line, Howard. Why don't you just try hello?
Howard: No, no, no, that always creeps girls out. I need to come up with something thats funny, smart and delicately suggests that my sexual endowment is disproportionate to my physical stature.
Leonard: You're going to need more than 11 hours.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: She calls me moon-pie because I'm nummy-nummy and she could just eat me up.

Leonard: Well, it looks like you're caught between a rock and a crazy place.
Sheldon: I hate when that happens.

Sheldon: No one calls me Moon Pie but Meemaw.