Priya: Oh, Sheldon. You haven't changed a bit, have you?
Sheldon: Why would I change?
Leonard: The hope has been that you'd eventually bend to public opinion.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: I'm sorry.
Raj's sister: Why do you say that?
Leonard: When I'm in bed with a girl, that's just my natural response.

Raj: Hands off my sister.
Sheldon: Why would I touch your sister? She's all covered in airplane germs.

Sheldon: And to think, I was about to waste the last of my good haemorrhoid cream on you.