Amy: Should you really be sitting in Sheldon's spot?
Raj: He's in Texas, he'll never know.
Penny: Wouldn't be so sure about that.
Leonard: Yeah, he has a very sensitive butt. Look, it's true. Once I saw him sit on a bunch of loose change and add it up.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Raj: It's too late. He's been murdered by someone in this room. Welcome to another classic Koothrappali murder mystery dinner.
Amy: I'm leaving.

Sheldon: Well then why are you doing it?
Mary: Because I'm not perfect, Shelly. And that man's booty is.