Penny: You know, you're the only person who could win the biggest prize in science and still be upset about it.
Sheldon: It's just all the times I thought about winning, I never thought about how it would ch-- affect my life. I'm sorry, I'm genuinely concerned about your liver.

Sheldon: But I do take your point. You know, you're also married, you have a successful career, you no longer dress like you're trying to attract sailors by the wharf.

Penny: You know, you go on and on about wanting things to stay the same, but you've changed a lot since I met you.
Sheldon: Oh, you are a mean drunk.

Penny: I'm serious. You have a ton of friends, you got married, moved into a new apartment, you wore a baseball hat that one time. Heck, you've had sex almost as many times as I have fingers.
Sheldon: More.
Penny: W-
Sheldon: By this many.
Penny: You dog!
Sheldon: It was the Avengers trailer.

Sheldon: How did you get down here?
Penny: The elevator. It's really fast.
Sheldon: I-I need to be alone right now. Don't try to follow me.
Penny: All right. You need a ride?
Sheldon: That'd be great. Thank you.

Sheldon: Hmm. What kind of tea is appropriate for winning a Nobel Prize and now everything is changing and you feel unmoored from reality?
Leonard: I don't know. Earl Grey?
Sheldon: You know, this is something I've wanted my whole life. But I guess I never considered how everything would be different.
Leonard: Buddy, I-I know it all feels overwhelming right now, but I promise you, things will settle down.
Sheldon: There's no Earl Grey! You filthy liar!

Amy: It's weird. I don't really feel different, but I guess our lives will never be the same.
Sheldon: Oh, I don't know. We're going to work like always. I still put my pants on both legs at a time.
Amy: One day that's gonna end very badly.

Sheldon: It's a congratulations text from my meemaw. [phone vibrates] Ooh. Oh, and there's one from my mom. [phone vibrates] And my sister. [phone vibrates] Oh, and my brother. [phone vibrates] And my brother's ex-wife. [phone vibrates] My brother's other ex-wife. Boy, they don't tell you when you win a Nobel it chews up your phone battery.

Amy: Oh. That's me. Hello? Yes, this is Dr. Fowler. I see. Okay, thank you. We won.
Penny: Congratulations!
Leonard: Oh, my God!
Sheldon: We did it.
Amy: I know. Can you believe it?
Sheldon: That's a good point. What if I'm dreaming? [Leonard slaps Sheldon] We won the Nobel Prize!

Sheldon: And how does it feel to be married to a Nobel Prize winner?
Amy: You tell me.
Sheldon: Oh. Amy-centric. What a fun way to look at it.
Amy: I think so.
Sheldon: You would. That makes sense.

Sheldon: You know, when you think about it, now that we're Nobel Prize winners, our names will be linked together forever.
Amy: We're married. Our names are already linked together forever.
Sheldon: Oh, please. That's just a piece of paper. This is a piece of paper and a medal.

Sheldon: Six times ten to the eighth atoms, Of a radium in a lead jar, Six times ten to the eighth atoms of radium, If the half-life of radium should happen to pass, Three times ten to the eighth atoms, Of a radium in a lead jar.
Penny: Really hope you're almost to zero.
Sheldon: No, see, that's the beauty of half-lives: it's impossible to determine when you'll arrive at zero. It's like "Wheels on the Bus" if the bus had an unknowable number of parts.

Penny: All right, now what?
Sheldon: Oh, why don't we play a game to pass the time? Here. Uh, I am thinking of a number. Hint: it's a cube of a cube of a prime.
Leonard: There's an infinite number of possibilities.
Sheldon: What, you got somewhere to be?

Leonard: When am I gonna stop trying to win her approval? E-Every time I'm around her, I-I turn into this needy little eight-year-old boy.
Sheldon: You sound like that now and she's not even here.

Leonard: I know that, it's just after all these years, you'd think I would have learned.
Sheldon: Hmm. It's too bad you didn't. Well, see? Compassion.