Amy: Watching your old friend?
Sheldon: Yes. Look at him, Amy. It's such a shame. Struck down in the prime of my life.

Sheldon: Amy, mourning the inevitable is a complete waste of time.
Amy: And watching a bunch of goofy space movies you've seen a hundred times isn't?
Sheldon: If we were in a physical relationship, you've just lost sex tonight.

Raj: Aren't you going to get 3D glasses?
Sheldon: I brought my own. No sense in risking "bridge of nose Herpes".
Raj: Is that a real thing?
Sheldon: Well, until they invent nose condoms, I'm not finding out.

Leonard: So, listen. There was something I was hoping to float past you. Now that Penny and I are engaged, I thought we might want to talk about our living arrangements.
Sheldon: Of course. She's spent many nights here, and you're worried about preserving the myth of her virginity before the wedding.
Leonard: I'm not.
Sheldon: Good. Because not only has that ship sailed, if it hit an iceberg countless men would perish.

Leonard: Maybe I'll move in with Penny, or maybe she and I'll take this place and you can move across the hall.
Sheldon: Move across the hall?! Did you take a marijuana?

Sheldon: I see. You're putting your future bride's happiness above mine.
Leonard: Well, yeah!
Sheldon: Wow.

Amy: You know, this might work out for the best. You're always complaining about what a terrible roommate Leonard is. Like how he turns up the thermostat when you're not there.
Sheldon: Euck, it's like walking into the Amazon. And not the good Amazon with one-day shipping, the awful one with birds and snakes.

Amy: Maybe you'll like living alone.
Sheldon: Perhaps.
Amy: And if you don't, maybe you and I could live together.
Sheldon: Oh, sure! While we're at it, why don't we get engaged, too? Why don't we get a little house, start a family, enjoy our sunset years together? Do you hear yourself woman?!

Sheldon: I'm helping you get back on your feet. I would like to purchase this comic book, please.
Stuart: It'll be $2.99.
Sheldon: Really? It's soaking wet.
Stuart: Fine, $1.

Leonard: Seriously? You don't even have a change of clothes or a toothbrush.
Sheldon: My plan is to stop at malls and buy what I need. It's called living off the land.

Howard: Since when do you read social science?
Sheldon: I go to the bathroom like everybody else.

Emily: I'm a resident at Huntington Hospital.
Sheldon: Oh, I like their emergency room. You know, even if it turns out you don't have Dengue Fever, they still let you take a lollipop.

Sheldon: Well, don't feel bad. I think we've all been distracted since the girls entered our lives.
Howard: You admit Amy's a distraction.
Sheldon: Oh very much so. Listen to this. This is from two days ago. "Hi, hope you're having a good day." Who has time for this constant sexting?

Sheldon: Therefore, the timeline in which 1955 Biff gets the almanac is also the timeline in which 1955 Biff never gets the almanac. And not just never gets, never have, never hasn't, never had have hasn't.

Raj: Okay. How about a little Miley Cyrus next?
Sheldon: Who's he?