Penny: Okay, Cat on a Hot Tin Roof is an American classic.
Sheldon: So is the McRib sandwich. I don't care for that either.

Penny: Just think about something else.
Sheldon: Can I think about the spiny anteater?
Penny: Sure.
Sheldon: The spiny anteater never went behind my back and worked with Barry Kripke.
That didn't help at all.

Sheldon: You just lied to Penny.
Leonard: Yes, I did.
Sheldon: And you did it so casually. No rapid breathing, no increase in perspiration.
Leonard: So?
Sheldon: So, lack of physiological response while lying is a characteristic of a violent sociopath.
Leonard: Sheldon, are you worried about your safety?
Sheldon: No. I imagine if you were going to kill me, you'd have done it a long time ago.

Penny: Leonard's had girls over before, right?
Sheldon: Oh, yes, but there's usually planning, courtship and advance notice. Last time I was able to book a cruise to the Arctic to see a solar eclipse.
Penny: Wait, you had to leave the state because your roommate was having sex?
Sheldon: I didn't have to, the dates just happened to coincide.

Sheldon: Do you like trains?
Priya: Not particularly.
Sheldon: You might as well just wait at the airport for your flight.

Leonard: Really? You're going to risk getting sleepy in the middle of your themodynamic fluctuations seminar? You know what happens when you yawn in public.
Sheldon: Everyone will see my oddly shaped uvula.

Sheldon: Would you like some advice?
Leonard: Sure, why not?
Sheldon: Then this is the perfect time to launch a blog with an interactive comments section.
Leonard: Gee, thanks a lot.

Penny: Ooh, I thought I smelled pizza.
Sheldon: That's remarkable. If pepperoni were an explosive substance, you could replace German shepherds at our nation's airports.

Penny: Today I drove to Van Nuys for an audition I thought was going to be for a cat food commercial. Turned out to be for porn.
Sheldon: Did you get the part?
Penny: I didn't do the audition.
Sheldon: Given the state of your career, can you really afford to be picky?

Penny: Sheldon, aren't you going to spend a little time with Amy?
Amy: Oh, it's okay, I'm used to it. The other day at Whole Foods, he spent an entire hour optimizing the cheese aisle.
Sheldon: Yeah, and some thanks I got. The assistant manager chased me out with an artisanal salami.

Sheldon: You know, surprisingly, the letter from your father wasn't the most interesting thing I read in the closet. Bernadette's diary has some saucy passages.
Bernadette: Sheldon, don't you dare.
Sheldon: There's nothing to worry about. Your secret's safe with me.
Bernadette: That's more like it.
Sheldon: Although copyright law would allow me to quote snippets in the context of a review.

Leonard: All right, you brought this on yourself. Sheldon, get him.
Sheldon: If a zombie bites you, you turn into a zombie. However, if a mummy bites you, all you turn into is some schmo with a mummy bite. So, like a zombie that's been eaten from the waist down, you, sir, have no leg to stand on.

Howard: He can't handle the fact that I'm a bigger deal than he is now.
Sheldon: Oh, preposterous. I have been solely responsible for this university's six loop quantum gravity calculations, I have changed the way we think about Bose-Einsten condensates, and I am also the one who got Nutter Butters in the cafeteria vending machine. Maybe you missed that news while you were floating around like a goof in outer space.

Sheldon: When Albert Einstein came up with special relativity, he was working at the patent office.
Leonard: So you're going to work at the patent office?
Sheldon: Don't be absurd. That's in Washington. You know I could never live in a city whose streets are laid out in a wheel-and-spoke pattern.

Employment adviser: So, Mr. Cooper, you're looking for a job?
Sheldon: A menial job. Like yours.
Employment adviser: Why thank you for noticing. I'm Menial Employee of the Month.