Penny: No, it's not that.
Bernadette: Then why?
Penny: Honestly, I don't know if I'm up to it. You know, the last project I managed was my high school yearbook.
Bernadette: And?
Penny: And that was the year we didn't have one. - And? And that was the year we didn't have one. Apparently, the printers won't make them without getting paid.
Bernadette: What happened to the money?
Penny: Uh, if I didn't know then, I'm not going to magically know now.

Bernadette: Look at Howard. He was a disaster when I met him. Now he's a foxy astronaut with a hot wife.
Raj: Wait, he always wanted to be an astronaut.
Bernadette: He thinks that, too. That's how good I am.

Sheldon: Oh, but don't worry. I won't do that to you.
Amy: Maybe you should.
Sheldon: What?
Amy: This has been your lifelong dream. And you may not get another chance. I don't want to be the reason that you don't win a Nobel.
Sheldon: You're the only reason I deserve one.

Amy: What's wrong?
Sheldon: Why do you assume something's wrong?
Amy: Because you haven't touched your dinner, and you're literally ticking like a bomb about to go off.
Sheldon: Oh, Amy. You see through me like one of Penny's shirts.

Amy: The last time we were in this room, we were getting married.
Sheldon: I remember. It's a lot less impressive without Mark Hamill in it.
Amy: That's what you said about our honeymoon.
Sheldon: And I stand by it.

Bernadette: Why don't you want to work with me? I know I can be tough, but that's just 'cause I'm surrounded by useless idiots.

Bernadette: Penny, everybody feels like you do. Like they're not good enough, not smart enough.
Penny: What, even you?
Bernadette: Of course.
Jess: Dr. Rostenkowski, you wanted me-
Bernadette: Hey, did they not teach knocking at Stanford? Get out! (chuckles) I love that kid.

Sheldon: Amy and I did this together, and I will not be part of an award that does not recognize the value of her contributions. So you either include both of us in the recommendation letter, or don't bother writing one.
President Siebert: I hope you know that's going to cause a fight between us and the Fermilab team.
Sheldon: If it's a fight that doesn't involve any touching, risk of physical harm or uncomfortable eye contact 'cause it's happening online or through intermediaries, I say bring it.

President Siebert: You know, Caltech has 38 Nobel laureates. If you win, you and Amy will be 39 and 40.
Sheldon: Ooh! Dibs on 39.
Amy: What's the difference?
Sheldon: Wha- You are right, there is no difference at all.

Sheldon: I'd like to start this episode by apologizing on behalf of Dr. Fowler, who made the wild claim last week that there was no national tricolored flag with a purple stripe, when, in fact, the Estonian governorate inside the Russian Empire had a purple stripe on their flag from 1721 to 1917. See? Right there in the middle.
Amy: And I'd like to apologize on behalf of Dr. Cooper for having his zipper down for the entire segment on the flags of East Africa.
Sheldon: Sorry, Tanzania, you deserve better.

Howard: So, my incredible wife has some exciting news.
Bernadette: Howie, stop. I don't want to brag.
Howard: Oh, okay, sorry.
Bernadette: Really? No one's gonna ask?
Leonard: Sorry. What's your news?
Bernadette: The drug I've been working on for the past five years just got approved by the FDA.
Penny: Wow.
Raj: Oh, congratulations. Was that the decongestant you developed?
Bernadette: No, we had to rebrand that as a solvent for mining equipment.

President Siebert: Just a heads-up. Doctors Pemberton and Campbell from Fermilab are flying to Los Angeles and they are eager to meet you.
Sheldon: Confirming my theory, eager to meet me. They are checking all my boxes.

Dr. Pemberton: It is such a pleasure to meet you.
Amy: Oh, it's really nice to meet you, too. I mean, we thought we'd have to wait decades to get confirmation for our theory.
Sheldon: Yes, thanks to you, I'll get to eat my Nobel dinner with my original teeth.

Raj: Oh, man, that last episode of Star Trek: Discovery was crazy.
Leonard: Whoa, whoa, whoa, I-I'm actually one behind.
Howard: I haven't started the new season yet.
Leonard: Ooh, uh, how about this week's Walking Dead?
Howard: Two behind.
Raj: Three behind.
Howard: Black Mirror?
Leonard: No.
Raj: No.
Leonard: Come on, there must be something we've all seen.
Raj: Oh, how about that video of my dog I sent you, where she's growling at a pinecone?
Howard: I actually hadn't watched it yet, but thanks for ruining the ending.

Sheldon: Uh, can you believe this? Doctors Pemberton and Campbell have been doing a press tour trying to take credit for super-asymmetry. They didn't even know what they were finding.
Raj: So what? I mean, no one's gonna give them credit for accidentally discovering something.
Howard: Yeah, who remembers the guy who was trying to find India and discovered America instead? What was his name again?